Endocrine Abstracts

Clinical case: A 27-year-old pregnant woman (24 weeks of gestation) was investigated as her Hb level (87 g/l) was low. Laboratory work-up revealed severe, non-PTH dependent hypercalcemia (see Table). This was her first pregnancy, and serum calcium measured once previously 12 years earlier had been normal. The patient had symptoms of increased thirst, constipation and hyperemesis.Diagnostic work up and Treatment: Rehydration and close mon...

Background: The best lateralization method to ascertain cure after surgery in unilateral primary aldosteronism (PA) is debated. Risk of persistent of PA in those with non-classical adrenal histopathology remains poorly characterized.Objective: We examined the value of anatomical compared with functional subtyping and the significance of immunohistochemical analysis of CYP11B1 and CYP11B2 for the outcome and histopathological diagnosis of primary aldoster...

Background: The cure of unilateral primary aldosteronism (PA) after adrenalectomy can result in complete, partial or absent biochemical and clinical improvement1. Histological findings from HE samples are of little assistance in determining if adenoma or hyperplastic adrenal tissue is hormonally overactive. Our aim in the present study was to compare immunohistochemical (IHC) CYP11B1 and CYP11B2 staining in adrenal slices to histological diagnosis based on H&E s...

Background: The prevalence of small intestine neuroendocrine tumors (SI-NETs) is increasing. Disease progression is often slow, treatment options and long-term survival rates have improved. Health-related quality of life (HRQoL) is considered an important measure of patients’ perception of the burden of their disease and the impact of treatment modalities. Despite this, data on whether improvements in treatment options and survival rates also translate into improved HRQoL...

Introduction: In multiple endocrine neoplasia 1 (MEN1), the decreased life expectancy is related especially to pancreatic neuroendocrine tumors (panNETs). Timely diagnosis of potentially aggressive panNETs is the cornerstone of the follow-up in MEN1. Somatostatin receptor positron emission tomography (SSTR PET/CT) has a high accuracy in the detection of neuroendocrine tumors. The role of this imaging modality in early diagnosis and follow-up of MEN1-related panNETs is unclear....

Background20–30% of patients with metastatic small intestine neuroendocrine tumours (SI-NETs) suffer from carcinoid syndrome (CS), i.e. diarrhea, flushing, and bronchospasm. Of these, 25–50% develop carcinoid heart disease (CHD) characterized by valve fibrosis and right heart failure. There are no early predictive markers of CHD, which typically is diagnosed in the advanced stage.Aims of the studyTo...

BackgroundAldosterone excess causes volume retention and cardiovascular damage. We evaluated the long-term haemodynamic changes in patients with targeted treatment of primary aldosteronism (PA) (n = 40) in comparison with essential hypertension (EH) (n = 40) and untreated normotensive controls (n = 40).MethodsPA patients were subjected to adrenal vein sampling and allocated to adren...